Medications helping fainting

7th March 2023 | Dr Boon Lim


Vasovagal syncope and orthostatic intolerance can significantly impact daily life, causing symptoms such as dizziness, lightheadedness, and fainting. Medications play a crucial role in the management of these conditions by improving blood pressure regulation and enhancing overall cardiovascular stability. This article focuses on three commonly prescribed medications—midodrine, fludrocortisone, and salt tablets—and their benefits in relieving symptoms associated with vasovagal syncope and orthostatic intolerance.


Midodrine is an alpha-adrenergic agonist that helps constrict blood vessels, thereby increasing peripheral resistance and improving blood pressure regulation. Here are key considerations:

– Mechanism of Action: Midodrine stimulates alpha-adrenergic receptors in blood vessels, causing vasoconstriction and elevating blood pressure.

– Benefits: By improving blood pressure control, midodrine can help alleviate symptoms of orthostatic hypotension (low blood pressure upon standing) such as dizziness, lightheadedness, and the risk of fainting.

– Usage and Dosage: Midodrine is typically taken orally, and the dosage is determined by a healthcare professional based on individual needs. It is often taken 2-3 times daily, with the last dose taken several hours before bedtime to prevent supine hypertension (high blood pressure while lying down).


Fludrocortisone is a mineralocorticoid that helps increase sodium reabsorption in the kidneys, promoting fluid retention and enhancing blood volume. Consider the following:

– Mechanism of Action: Fludrocortisone acts on the kidneys to increase the reabsorption of sodium and water, thereby expanding blood volume and improving blood pressure control.

– Benefits: By optimizing blood volume, fludrocortisone can help alleviate symptoms of orthostatic hypotension and improve overall cardiovascular stability.

– Usage and Dosage: Fludrocortisone is typically taken orally once daily. The dosage is determined by a healthcare professional based on individual needs, and it is important to monitor blood pressure and electrolyte levels regularly while on this medication.

Salt Tablets

Salt tablets or capsules contain concentrated amounts of sodium chloride and are used to supplement sodium levels in individuals with low blood pressure and sodium loss. Here are key considerations:

– Mechanism of Action: Salt tablets provide additional sodium, which helps increase blood volume and improve blood pressure regulation.

– Benefits: By supplementing sodium levels, salt tablets can help alleviate symptoms of orthostatic hypotension, particularly in individuals with sodium loss or low blood pressure.

– Usage and Dosage: The usage and dosage of salt tablets should be determined in consultation with a healthcare professional, who can guide individuals on the appropriate amount of sodium supplementation needed based on individual requirements.


Medications such as midodrine, fludrocortisone, and salt tablets play a valuable role in the management of vasovagal syncope and orthostatic intolerance. Midodrine helps improve blood pressure regulation through vasoconstriction, while fludrocortisone optimizes blood volume through sodium retention. Salt tablets provide supplemental sodium to support blood volume and blood pressure stability. It is important to note that medication usage should be determined and monitored by healthcare professionals, who can tailor treatment plans to individual needs. By incorporating these medications as part of a comprehensive treatment approach, individuals with vasovagal syncope and orthostatic intolerance can experience symptom relief, improved quality of life, and enhanced cardiovascular stability.

While midodrine, fludrocortisone, and salt tablets can be effective in managing symptoms of vasovagal syncope and orthostatic intolerance, they can also have potential side effects. It is important to be aware of these side effects and discuss them with a healthcare professional before starting any medication. Here are some common side effects associated with each medication:


– Supine Hypertension: Midodrine can cause high blood pressure while lying down (supine hypertension). To minimize this risk, the last dose should be taken several hours before bedtime.

– Pilomotor reactions: Midodrine can cause pilomotor reactions, resulting in goosebumps and scalp tingling.

– Urinary Retention: Some individuals may experience difficulty in emptying the bladder, leading to urinary retention.

– Scalp and Skin Tingling: Midodrine may cause tingling sensations or a feeling of “pins and needles” on the scalp or skin.


– Fluid Retention and Edema: Fludrocortisone can lead to fluid retention, which may cause swelling (edema) in the legs, ankles, or other areas of the body.

– High Blood Pressure: Fludrocortisone can increase blood pressure, so regular monitoring is important.

– Electrolyte Imbalances: Fludrocortisone may affect electrolyte levels, particularly potassium. Regular monitoring of electrolyte levels is essential.

Salt Tablets:

– Fluid Retention and Edema: Increasing sodium intake through salt tablets can cause fluid retention and edema, especially in individuals who are prone to retaining fluids.

– Increased Blood Pressure: Higher sodium intake may contribute to elevated blood pressure, so monitoring blood pressure regularly is important.

– Electrolyte Imbalances: Sodium supplementation can impact electrolyte balance, so monitoring electrolyte levels is crucial.

It’s important to note that individual responses to medications can vary, and not everyone may experience these side effects. However, if any side effects are noticed while taking these medications, it is essential to inform a healthcare professional. They can provide guidance, monitor for potential complications, and make necessary adjustments to the treatment plan to ensure the best possible outcomes.

Remember, the benefits of these medications often outweigh the potential side effects, but close monitoring and regular communication with a healthcare professional are key to managing any medication regimen effectively.

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